📘 ❞ Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients ❝ بحث أكاديمي اصدار 2023

كتب الطب البشري - 📖 بحث أكاديمي ❞ Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients ❝ ــ مجموعة من المؤلفين 📖

█ _ مجموعة من المؤلفين 2023 حصريا بحث أكاديمي ❞ Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients ❝ عن جميع الحقوق محفوظة للمؤلف 2025 Patients: This study's objective is to assess the prognostic value serum level admission bio ADM critically ill patients In this observational prospective study, who were admitted Minia University Hospitals' medical critical care unit between December 2020 and November 2021 underwent a complete blood count, CRP , renal liver function tests culture All had their adrenomedullin levels evaluated by ELISA at time The work included 114 subdivided into 3 groups: non septic group including SIRS with negative (n=44), mild sepsis SOFA score ≥2 without organ dysfunction (n=26), severe (n=44) There was significant difference distribution quartiles survivor survivors Most our cohort 4th quartile (38 9%) while 45% 1st Bio positively correlated (r value: 0 65, p < 001) 63, Using receiver operating characteristic (ROC) curve determine accuracy ADM, CRP, revealed higher area under (AUC) for (0 78, 95% CI: 69 86) followed 66, 56 76) 52 73) best cut off predict ICU mortality 121 5 pg ml sensitivity 85% specificity 61% كتب الطب البشري مجاناً PDF اونلاين هو أكثر التخصصات التي تفيد المجتمع وأكثرها تواصلاً معه يشارك الطبيب العديد الحملات الصحية التثقيفية والمشاركة البرامج الوقائية وحماية البيئة واستخدام كل وسيلة فعَّآلة لتحقيق ذلك ويساهم أيضاً رفع مستوى الوعي الصحي وتقديم المشورة للمجتمع يحتوي هذا القسم علي الكتب المتميزة تشمل: الإلمام الكامل بالأمراض تصيب جسم الإنسان والأعراض المصاحبة لهذه الأمراض وطرق تطوير صحة ويتخصص المجال أطباء يحصلون شهادة MD وهي أول الشهادات يحصل عليها المبتدأ مجال الطب

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Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients
بحث أكاديمي

Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients

صدر 2023م
Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients
بحث أكاديمي

Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients

صدر 2023م
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عن بحث أكاديمي Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients:
This study's objective is to assess the prognostic value of the serum level of admission bio-ADM in critically ill patients. In this observational prospective study, patients who were admitted to Minia University Hospitals' medical critical care unit between December 2020 and November 2021 underwent a complete blood count, CRP , renal and liver function tests and blood culture.

All patients had their bio-adrenomedullin levels evaluated by ELISA at the time of admission. The work included 114 patients who were subdivided into 3 groups: non-septic group including SIRS patients with negative blood culture (n=44), mild sepsis group including patients with SOFA score ≥2 without organ dysfunction (n=26), and severe sepsis group including sepsis patients with organ dysfunction (n=44). There was a significant difference in distribution of the quartiles of bio-ADM between survivor and non-survivors. Most of the non-survivors in our cohort were in the 4th quartile of bio-ADM (38.9%) while 45% of the survivors were in the 1st quartile of bio-ADM.

The levels of Bio-ADM were positively correlated with CRP (r-value: 0.65, p-value < 0.001) and SOFA score (r-value: 0.63, p-value < 0.001). Using receiver operating characteristic (ROC) curve to determine the prognostic accuracy of bio-ADM, CRP, and SOFA score revealed higher area under curve (AUC) for bio-ADM (0.78, 95% CI: 0.69-0.86) followed by CRP (0.66, 95% CI: 0.56-0.76) and SOFA score (0.63, 95% CI: 0.52-0.73). The best cut-off for bio-ADM to predict ICU mortality in our cohort was 121.5 pg/ml with a sensitivity of 85% and a specificity of 61%.
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Authors

Hager Abd El Fatah 1 Osama Al-Minshawy 1 Ali abdelaziz 2 Ahmed Saedii 3 Mohamed Abd El Aziz 1
1 Internal Medicine Department, Faculty of Medicine, Minia University

2 Chest Department, Faculty of Medicine, Minia University

3 Clinical Pathology Department, Faculty of Medicine, Minia University

10.21608/UECCJ.2023.194898.1004
شارك في التأليف:
Authors

Hager Abd El Fatah 1 Osama Al-Minshawy 1 Ali abdelaziz 2 Ahmed Saedii 3 Mohamed Abd El Aziz 1
1 Internal Medicine Department, Faculty of Medicine, Minia University

2 Chest Department, Faculty of Medicine, Minia University

3 Clinical Pathology Department, Faculty of Medicine, Minia University

10.21608/UECCJ.2023.194898.1004
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