📘 ❞ Alpha-adrenoceptors in equine digital veins Evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction ❝ كتاب
كتب طب بيطرى - 📖 كتاب ❞ Alpha-adrenoceptors in equine digital veins Evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction ❝ 📖
█ _ 0 حصريا كتاب ❞ Alpha adrenoceptors in equine digital veins Evidence for the presence of both alpha1 and alpha2 receptors mediating vasoconstriction ❝ 2024 vasoconstriction: Alphaadrenoceptors alpha2receptors من كتب طب بيطرى J vet Pharmacol Therap 20, 308±317, 1997 SYSTEMIC PHARMACOLOGY Alpha veins: of both vasoconstriction Elliott, J presence of Pharmacol 308±317 Rings vein examined under conditions isometric tension recording constricted to alpha adrenoceptor agonists with an order potency of 5 bromo 6 [2 imidazolin 2 yl amino] quinoxaline bitartrate (UK 14304) = noradrenaline 4 Allyl amino 5,6,7,8 tetrahydro 4H thiazolo (4,5 d) azepine (BHT 920) phenylephrine dopamine methoxamine The maximum force generated was greatest non selective agonist noradrenaline and lowest BHT 920 other agonists between these two extremes Selective inactivation adrenoceptors (achieved by treating yohimbine protected tissues phenoxybenzamine) reduced maximum responses all agonists, EC50 values UK 14304, BHT increased phenylephrine and Prazosin (30 nM) had no inhibitory effect on to low concentrations 14304 caused competitive inhibition giving pKb of 8 49+0 18 8 23+0 14, respectively Yohimbine (0 1 mM) caused significant competitive inhibition noradrenaline with calculated 43+0 11 7 31 for noradrenaline methoxy 1,4 benzodioxan yl] imidazoline (RX 821002; 10 caused competitive (pKb 9 04+0 27) and dopamine 2+0 2) These data indicate that possess both post synaptic (Paper received November 1996; accepted publication April 1997) Jonathan Elliott, Department Veterinary Basic Sciences, Royal College, Royal College Street, London NW1 0TU, مجاناً PDF اونلاين الطب البيطري (بالإنجليزية: medicine) أو البيطرة هو تطبيق المبادئ الطبية والتشخيصية والعلاجية الحيوانات الإنتاجية والمنزلية والبرية يحتوي هذا القسم علي العديد الكتب المتميزة حول المجال يمارس عادة عيادة بيطرية مستشفى بيطري المزرعة للطب دور كبير حماية البشر الأمراض التي تنتقل عن طريق الأكل أصبح التخصص شائعاً السنوات الأخيرة ومن تلك التخصصات: التخدير علم السلوك الجلدية الحالات الطارئة والعناية الحثيثة الباطني امراض القلب السرطان العيون الأعصاب المشتركة المعدية التناسليات والولادة التصوير الشعاعي والجراحة
كتاب
Alpha-adrenoceptors in equine digital veins Evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction
كتاب
Alpha-adrenoceptors in equine digital veins Evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction
Alphaadrenoceptors in equine digital veins Evidence for the presence of both alpha1 and alpha2receptors mediating vasoconstriction من كتب طب بيطرى
J. vet. Pharmacol. Therap. 20, 308±317, 1997. SYSTEMIC PHARMACOLOGY
Alpha-adrenoceptors in equine digital veins: Evidence for the presence of
both alpha1 and alpha2-receptors mediating vasoconstriction
Elliott, J. Alpha-adrenoceptors in equine digital veins: Evidence for the presence
of both alpha1 and alpha2-receptors mediating vasoconstriction. J. vet.
Pharmacol. Therap. 20, 308±317.
Rings of equine digital vein examined under conditions of isometric tension
recording constricted to alpha-adrenoceptor agonists with an order of potency
of 5-bromo-6-[2-imidazolin-2-yl-amino]-quinoxaline bitartrate (UK 14304) =
noradrenaline 4 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-(4,5-d) azepine
(BHT-920) 4 phenylephrine 4 dopamine 4 methoxamine. The maximum
force generated was greatest for the non-selective agonist noradrenaline and
lowest for the alpha2-selective agonist BHT-920 with the other agonists
between these two extremes. Selective inactivation of alpha1-adrenoceptors
(achieved by treating yohimbine-protected tissues with phenoxybenzamine)
reduced the maximum responses of all agonists, the EC50 values of UK 14304,
BHT-920 and noradrenaline and increased the EC50 values of phenylephrine
and methoxamine. Prazosin (30 nM) had no inhibitory effect on responses to
low concentrations of BHT-920 and UK 14304 and caused competitive
inhibition of responses to phenylephrine and noradrenaline giving pKb values of
8.49+0.18 and 8.23+0.14, respectively. Yohimbine (0.1 mM) caused
significant competitive inhibition of responses to BHT-920 and noradrenaline
with calculated pKb values of 8.43+0.11 for BHT-920 and 7.43+0.31 for
noradrenaline and non-competitive inhibition of responses to UK 14304. 2-[2-
methoxy-1,4-benzodioxan-2-yl]-2-imidazoline (RX 821002; 10 nM) caused
competitive inhibition of responses to BHT-920 (pKb 9.04+0.27) and
dopamine (pKb 8.2+0.2). These data indicate that equine digital veins possess
both post-synaptic alpha1 and alpha2-adrenoceptors.
(Paper received 4 November 1996; accepted for publication 11 April 1997)
Jonathan Elliott, Department of Veterinary Basic Sciences, Royal Veterinary College,
Royal College Street, London NW1 0TU, UK.
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